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Jain, Vineet C.
- Simultaneous Determination of Mesalazine and Rifaximin in Synthetic Mixture Using Spectrophotometric Technique (Simultaneous Equation Method)
Authors
1 Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 2 (2016), Pagination: 61-67Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Mesalazine and Rifaximin in synthetic mixture using Simultaneous Equation Method. The absorbance was measured at 328 nm for Mesalazine and 292nm for Rifaximin and calibration curves were plotted as absorbance versus concentration, respectively. The method was found to be linear (r2> 0.999) in the range of10-50 μg/ml for Mesalazine at 328nm. The linear correlation was obtained (r2> 0.999) in the range of 10-50 μg/ml for Rifaximin at 292nm. The limit of determination (LOD) was 0.215μg/ml and 0.214μg/ml for Mesalazine and Rifaximin respectively. The limit of quantification (LOQ) was 0.652μg/ml and 0.648 μg/ml for Mesalazine and Rifaximin respectively. The accuracy of this method was evaluated by recovery studies and good recovery results were obtained greater than 99%.The method was successfully applied for simultaneous determination of Mesalazine and Rifaximin in binary mixture.Keywords
Mesalazine, Rifaximin, Simultaneous Estimation, Simultaneous Equation Method.- Simultaneous Determination of Saxagliptin Hydrochloride and Glibenclamide in Synthetic Mixture Using Spectrophotometric Technique (First Order Derivative Method)
Authors
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 2 (2016), Pagination: 77-82Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Saxagliptin Hydrochloride and Glibenclamide in synthetic mixture using first order derivative zero-crossing method. Saxagliptin Hydrochloride showed zero crossing point at 315.00nm while Glibenclamide showed zero crossing point at 229.40nm. The dA/dλ was measured at 229.40nm for Saxagliptin Hydrochloride and 315.00nm for Glibenclamide and calibration curves were plotted as dA/dλ versus concentration, respectively. The method was found to be linear (r2>0.9995) in the range of 5-25μg/ml for Saxagliptin Hydrochloride at 229.40nm. The linear correlation was obtained (r2>0.9994) in the range of 5-25 μg/ml for Glibenclamide at 315.00nm. The limit of determination was 0.243μg/ml and 0.317μg/ml for Saxagliptin Hydrochloride and Glibenclamide, respectively. The limit of quantification was 0.738μg/ml and 0.960μg/ml for Saxagliptin Hydrochloride and Glibenclamide respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Saxagliptin Hydrochloride and Glibenclamide in binary mixture.Keywords
Saxagliptin Hydrochloride, Glibenclamide, First Derivative Method, Spectroscopic Method.- Simultaneous Estimation of Lamotrigine and Clozapine by Simultaneous Equation Method in their Synthetic Mixture which Use in Schizophrenia
Authors
1 Shree Dhanvantary Pharmacy Collage, Kim, Surat, Gujarat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 2 (2015), Pagination: 79-85Abstract
Two simple spectroscopic methods have been developed for simultaneous estimation of Lamotrigine and Clozapine in synthetic mixture. Simultaneous equation method involves the measurement of absorption at two wavelengths 308 nm (λmax for Lamotrigine) and 259.60 nm (λmax for Clozapine). The method was found linear between the range of 1-5 μg/ml for Lamotrigine and 6-30 μg/ml for Clozapine for method .The accuracy and precision was determined and validated statistically. Both the method showed good reproducibility and recovery with %RSD less than 1.The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis for Lamotrigine and Clozapine in bulk and combined dosage form.Keywords
Lamotrigine, Clozapine, Simultaneous Equation Method.- Simultaneous Determination of Cilnidipine and Valsartan in Synthetic Mixture Using Spectrophotometric Technique (Simultaneous Equation Method)
Authors
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 1 (2015), Pagination: 21-25Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimationof Cilnidipine and Valsartan in synthetic mixture using Simultaneous Equation Method. The absorbance was measured at 240.00nm for Cilnidipine and 250.00nm for Valsartan and calibration curves were plotted as absorbance versus concentration, respectively. The method was found to be linear (r2>0.999) in the range of 2-10μg/ml for Cilnidipine at 240.00nm. The linear correlation was obtained (r2>0.999) in the range of 16-80μg/ml for Valsartan at 250.00nm. The limit of determination (LOD) was 0.07 μg/ml and 0.266μg/ml for Cilnidipine and Valsartan respectively. The limit of quantification (LOQ) was 0.22μg/ml and 0.808μg/ml for Cilnidipine and Valsartan respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99%.The method was successfully applied for simultaneous determination of Cilnidipine and Valsartan in binary mixture.Keywords
Cilnidipine, Valsartan, Simultaneous Estimation, Simultaneous Equation Method.- Absorbance Correction Method for Simultaneous Estimation of Amlodipine Besylate and Simvastatin in Synthetic Mixture
Authors
1 Department of Quality Assurance, Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 2 (2015), Pagination: 78-82Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Amlodipine besylate and Simvastatin in synthetic mixture using Absorbance correction method. At 360.80 nm (λmax of Amlodipine besylate) Simvastatin has zero absorbance so Amlodipine besylate is directly estimate at 360.80 nm. At 237.60 nm (λmax of Simvastatin) both drugs have some absorbance so Simvastatin is estimate at 237.60 nm using absorbance correction method.The method was found to be linear (r2>0.999) in the range of 5-10 μμg/ml for Amlodipine besylate at 360.80 nm. The linear correlation was obtained (r2>0.999) in the range of 5-10 μg/ml for Simvastatin at 237.60 nm. The limit of determination was 0.17 μg/ml and 0.10 μg/ml for Amlodipine besylate and Simvastatin, respectively. The limit of quantification was 0. 54μg/ml and 0. 32μg/ml for Amlodipine besylate and Simvastatin, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99%. The method was successfully applied for simultaneous determination of Amlodipine besylate and Simvastatin in binary mixture.Keywords
Amlodipine Besylate, Simvastatin, Absorption Correction Method.- Development and Validation of Ratio Derivative Spectrophotometric Method for Estimation of Metronidazole Benzoate and Related Impurity in Bulk and Pharmaceutical Formulation
Authors
1 Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, IN
2 Shree Dhanvantary Pharmaceutical Analysis & Research Centre, Kim, Surat, Gujarat, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 2 (2015), Pagination: 66-70Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Metronidazole Benzoate and related impurity in bulk and pharmaceutical formulation by ratio derivative simultaneous equation method. The method is based on dividing the spectrum for a mixture into the standard spectra for each of the analysis and to obtain a spectrum that is independent of the analyte concentration used as a divisor. In this method for MND, MNI and BA the linearity range 2.0-10 μg/ml were divided by the divisor 2.0 μg/ml of MTZ. The use of standardized spectra as divisors minimizes experimental errors. Ratio spectra derivative permits the use of the wavelengths corresponding to maximum or minimum and also the use of the distance between consecutive maximum and minimum. For that the divided spectra was converted to second derivative using DL value 16 and SF value 100. The Metronidazole shows max absorbance at 270.00 nm, 2- Methyl-5Nitroimidazole show max absorbance at 257.42 nm and Benzoic Acid shows max. absorbance at 245.61 nm. The method was found to be linear (r2>0.997) in the range of 2.0-10 μg/ml. The limit of determination was 0.049 μg/ml and 0.026 μg/ml and0.038 μg/ml for Metronidazole, 2-Methyl-5-Nitroimidazole and Benzoic Acid, respectively. The limit of quantification was 0.150 μg/ml and 0.079 μg/ml and 0.115 μg/ml for Metronidazole, 2-Methyl-5-Nitroimidazole and Benzoic Acid, respectively. The accuracy of this method was evaluated by recovery studies and good recovery result was obtained 100%. The method was successfully applied for simultaneous determination of Metronidazole, 2-Methyl-5-Nitroimidazole and Benzoic Acid.Keywords
Metronidazole Benzoate, Metronidazole, 2-Methyl-5-Nitroimidazole, Benzoic Acid, Ratio Derivative Simultaneous Equation Method.- First Derivative Spectroscopic Method for Simultaneous Estimation of Pravstatin and Valsartan in Synthetic Mixture
Authors
1 Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 2 (2015), Pagination: 83-90Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Pravastatin and Valsartan in synthetic mixture using first order derivative zero-crossing method. Pravastatin showed zero crossing point at 262.40 nm while Valsartan showed zero crossing point at 248.20 nm. The dA/dλ was measured at 248.20 nm for Pravastatin and 262.80 nm for Valsartan and calibration curves were plotted as dA/dλ versus concentration, respectively. The method was found to be linear (r2>0.999) in the range of 2-10μg/ml for Pravastatin at 248.20 nm. The linear correlation was obtained (r2>0.9998) in the range of 8-40μg/ml for Valsartan at 262.40 nm. The limit of determination was 0.054μg/ml and 0.024μg/ml for Pravastatin and Valsartan, respectively. The limit of quantification was 0.166μg/ml and 0.074μg/ml for Pravastatin and Valsartan, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Pravastatin and Valsartan in binary mixture.Keywords
Pravastatin, Valsartan, First Derivative Method, Spectroscopic Method.- First Derivative Spectroscopic Method for Simultaneous Estimation of Edaravone and Argatroban in Synthetic Mixture
Authors
1 Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 1 (2015), Pagination: 18-26Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Edaravone and Argatroban in synthetic mixture using first order derivative zero-crossing method. Edaravone showed zero crossing point at 351.00 nm while Argatroban showed zero crossing point at 280.47 nm. The dA/dλ was measured at 280.47 nm for Edaravone and 351.00nm for Argatroban and calibration curves were plotted as dA/dλ versus concentration, respectively. The method was found to be linear (r2>0.998) in the range of 10-35μg/ml for Edaravone at 280.47 nm. The linear correlation was obtained (r2>0.999) in the range of 10-35 μg/ml for Argatroban at 351.0 nm. The limit of determination was 1.59μg/ml and 1.87μg/ml for Edaravone and Argatroban, respectively. The limit of quantification was 4.83 μg/ml and 5.68 μg/ml for Edaravone and Argatroban, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Edaravone and Argatroban in binary mixture.Keywords
Edaravone, Argatroban , First Derivative Method, Spectroscopic Method.- Absorbance Correction Method for Simultaneous Estimation of Edaravone and Argatroban in Synthetic Mixture
Authors
1 Shree Dhanvantary College of Pharmacy, Kim, Surat, Gujarat, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 1 (2015), Pagination: 41-48Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Edaravone and Argatroban in synthetic mixture using Absorbance correction method. At 333 nm (λmax of Argatroban) Edaravone has zero absorbance so Argatroban is directly estimate at 333 nm. At 242 nm (λmax of Edaravone) both drugs have some absorbance so Edaravone is estimate at 242 nm using absorbance correction method.
The method was found to be linear (r2>0.992) in the range of 10-35μg/ml for Edaravone at 242 nm. The linear correlation was obtained (r2>0.998) in the range of 10-35 μg/ml for Argatroban at 333 nm. The limit of determination was 0.060 μg/ml and 0.208μg/ml for Edaravone and Argatroban, respectively. The limit of quantification was 0.184μg/ml and 0.631μg/ml for Edaravone and Argatroban, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99%. The method was successfully applied for simultaneous determination of Edaravone and Argatroban in binary mixture.